Archives of Dermatological Research

, Volume 284, Issue 2, pp 82–85

Immunohistochemical studies on NAP-1/IL-8 in contact eczema and atopic dermatitis

  • M. Sticherling
  • E. Bornscheuer
  • J.-M. Schröder
  • E. Christophers
Original Contributions

DOI: 10.1007/BF00373374

Cite this article as:
Sticherling, M., Bornscheuer, E., Schröder, JM. et al. Arch Dermatol Res (1992) 284: 82. doi:10.1007/BF00373374

Summary

The neutrophil activating peptide NAP-1/IL-8 has in the past been shown to be secreted by diverse cell-types involved in inflammatory processes. Furthermore, potent biological effects on both neutrophilic granulocytes and lymphocytes enforce its role in inflammation. Recently, immunohistochemical studies using monoclonal anti-NAP-1/IL-8 antibodies have been performed on dermal inflammatory conditions like psoriasis vulgaris. These have demonstrated epidermal IL-8 immunoreactivity in a pattern inversely related to the degree of inflammatory infiltration. Based on these results, in the present study biopsies from patients with contact eczema as well as atopic dermatitis were examined. The same patterns of immunoreactivity were found with either homogenous epidermal staining, focally negative staining or overall decreased or even absent staining. As in psoriasis, these patterns were related to the degree of inflammatory infiltration. These results prove NAP-1/IL-8 to be involved not only in psoriasis vulgaris, but more likely to be a marker of different inflammatory processes. Future work will have to examine the kinetics as well as stimuli causing these effect.

Key words

Neutrophil activating peptide (NAP-1/IL-8)Contact eczemaAtopic dermatitisInflammation

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • M. Sticherling
    • 1
  • E. Bornscheuer
    • 1
  • J.-M. Schröder
    • 1
  • E. Christophers
    • 1
  1. 1.Department of DermatologyUniversity of KielKielGermany