Archives of Dermatological Research

, Volume 285, Issue 7, pp 432–435

Anti-inflammatory effects of eicosapentaenoic acid on experimental skin inflammation models

  • K. Danno
  • K. Ikai
  • S. Imamura
Original Contributions

DOI: 10.1007/BF00372139

Cite this article as:
Danno, K., Ikai, K. & Imamura, S. Arch Dermatol Res (1993) 285: 432. doi:10.1007/BF00372139

Abstract

Anti-inflammatory effects of eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) were examined on three models of skin inflammation induced in mice by topical application of an arachidonic acid (AA) solution, ultraviolet-B (UVB) irradiation, and contact sensitization with dinitrofluorobenzen. Ear oedema reactions induced by AA and UVB irradiation were significantly suppressed in mice fed a daily dose of 300 mg/kg EPA for 2 weeks. The contact hypersensitivity reaction was not impaired by EPA. None of the skin reactions was significantly inhibited in mice fed DHA or safflower oil. The results suggest that EPA, but not DHA, has anti-inflammatory effects on AA- and UVB-induced acute inflammation reactions.

Key words

Anti-inflammatory effectDocosahexaenoic acidEar oedemaEicosapentaenoic acidUltraviolet radiation

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • K. Danno
    • 1
  • K. Ikai
    • 2
  • S. Imamura
    • 2
  1. 1.Department of DermatologyShiga University of Medical ScienceOtsuJapan
  2. 2.Department of DermatologyKyoto University Faculty of MedicineKyotoJapan