Pflügers Archiv

, Volume 416, Issue 1, pp 219–221

The effects of 2,3-butanedione monoxime on initial heat, tension, and aequorin light output of ferret papillary muscles

  • E. M. Blanchard
  • G. L. Smith
  • D. G. Allen
  • N. R. Alpert
Short Communication Heart Circulation Respiration and Blood; Environmental and Exercise Physiology

DOI: 10.1007/BF00370248

Cite this article as:
Blanchard, E.M., Smith, G.L., Allen, D.G. et al. Pflügers Arch (1990) 416: 219. doi:10.1007/BF00370248

Abstract

At low concentrations (up to 5 mM) the compound 2,3-butanedione monoxime (BDM) was found to reduce twitch tension and initial heat production in isolated papillary muscles without significantly affecting the size of the intracellular Ca transient measured with aequorin luminescence. Higher concentrations of BDM caused further inhibition of twitch tension and heat production with a fall in the size of the Ca+ transient. The size of the aequorin transient was 50% of the control value at 15 mM BDM while twitch tension was negligible. These results suggest that BDM selectively inhibits Ca2+ activated force in cardiac muscle at low concentrations with additional effects on intracellular calcium at concentrations above 5 mM.

Key Words

Cardiac musclebutanedione monoximeheat productionaequorin luminescence

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • E. M. Blanchard
    • 1
  • G. L. Smith
    • 2
    • 3
  • D. G. Allen
    • 2
  • N. R. Alpert
    • 1
  1. 1.Department of PhysiologyUniversity of VermontBurlingtonUSA
  2. 2.Department of PhysiologyUniversity College LondonLondonGB
  3. 3.Institute of PhysiologyGlasgow UniversityGlasgowGB