Mammalian Genome

, Volume 5, Issue 8, pp 503–508

Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human

Authors

  • R. E. Magenis
    • Department of Molecular and Medical GeneticsOregon Health Sciences University
    • Child Development and Rehabilitation CenterOregon Health Sciences University
  • L. Smith
    • Department of Molecular and Medical GeneticsOregon Health Sciences University
    • Child Development and Rehabilitation CenterOregon Health Sciences University
  • J. H. Nadeau
    • The Jackson Laboratory
  • K. R. Johnson
    • The Jackson Laboratory
  • K. G. Mountjoy
    • Vollum Institute for Advanced Biomedical ResearchOregon Health Sciences University
  • R. D. Cone
    • Vollum Institute for Advanced Biomedical ResearchOregon Health Sciences University
Original Contributions

DOI: 10.1007/BF00369320

Cite this article as:
Magenis, R.E., Smith, L., Nadeau, J.H. et al. Mammalian Genome (1994) 5: 503. doi:10.1007/BF00369320

Abstract

The melanocortin peptides regulate a wide variety of physiological processes, including pigmentation and glucocorticoid production, and also have several activities in the central and peripheral nervous systems. The melanocortin receptor family includes the melanocytestimulating hormone receptor (MSH-R), adrenocorticotropic hormone receptor (ACTH-R), and two neural receptors, MC3-R and MC4-R. In the human these receptors map to 16q24 (MSH-R), 18p11.2 (ACTH-R), 20q13.2 (MC3-R), and 18q22 (MC4-R). The corresponding locations in the mouse are 8, 18, and 2; a variant for mapping MC4-R has not yet been identified. The data reported here also show that the neural MC3 receptor maps close to a disease locus for benign neonatal epilepsy in human and near the El-2 epilepsy susceptibility locus in the mouse.

Copyright information

© Springer-Verlag New York Inc. 1994