Current Genetics

, Volume 13, Issue 2, pp 129–135

Nuclear omnipotent suppressors of premature termination codons in mitochondrial genes affect the 37S mitoribosomal subunit

Authors

  • Magdalena Boguta
    • Institute of Biochemistry and BiophysicsPolish Academy of Sciences
  • Maria Mieszczak
    • Institute of Biochemistry and BiophysicsPolish Academy of Sciences
  • Wlodzimierz Zagórski
    • Institute of Biochemistry and BiophysicsPolish Academy of Sciences
Original Articles

DOI: 10.1007/BF00365647

Cite this article as:
Boguta, M., Mieszczak, M. & Zagórski, W. Curr Genet (1988) 13: 129. doi:10.1007/BF00365647

Summary

nam3 and R705, yeast nuclear omnipotent suppressors of mitochondrial mit mutations, reverse the superimposed spectrum of trans-recessive splicing defects by affecting the protein composition of the small mitoribosomal subunit. Analysis of the suppressor's interaction suggests that suppression results from mutations in the mitoribosomal polypeptides. These data indicate an obligatory connection between mitoribosome function and splicing of introns bI2, bI4 and aI1 in yeast mitochondria.

Key words

Mitochondrial ribosomesSuppressornam mutants

Copyright information

© Springer-Verlag 1988