Immunogenetics

, Volume 16, Issue 1, pp 47–58

Immunodominance in the immune response to “multiple” histocompatibility antigens

  • Peter J. Wettstein
  • Donald W. Bailey
Original Investigations

DOI: 10.1007/BF00364441

Cite this article as:
Wettstein, P.J. & Bailey, D.W. Immunogenetics (1982) 16: 47. doi:10.1007/BF00364441

Abstract

Cytotoxic effector T cells putatively specific for multiple non-H-2 histocompatibility (H) antigens were generated by immunizing and boosting C57BL/6 and B6.C-H-2dmice with BALB.B and BALB/c stimulator cells, respectively. The generated effectors were tested for cell-mediated lympholysis on a panel of targets whose BALB/c-derived non-H-2 H antigens were donated by CXB recombinant inbred mice. The spectrum of reactivity of cytotoxic effector T cells with CXB targets demonstrated that the effectors did not recognize multiple H antigens but rather preferentially recognized a single immunodominant non-H-2 H antigen. The identity of the immunodominant H antigen was determined by the H-2 genotype of the stimulator cells when (B6 × B6.C-H-2d)F1 cytotoxic effectors were tested. These observations indicate that despite the fact that responders were challenged with more than 40 individual non-H-2 H antigens, they preferentially responded to a single immunodominant antigen.

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Peter J. Wettstein
    • 1
  • Donald W. Bailey
    • 2
  1. 1.The Wistar Institute of Anatomy and BiologyPhiladelphia
  2. 2.The Jackson LaboratoryBar Harbor