Current Genetics

, Volume 11, Issue 4, pp 295–301

A mitochondrial frameshift-suppressor (+) of the yeast S. cerevisiae maps in the mitochondrial 15S rRNA locus

Authors

  • Brigitte Weiss-Brummer
    • Institut für Genetik und Mikrobiologie, Lehrstuhl für GenetikUniversität München
  • Hajime Sakai
    • Institut für Genetik und Mikrobiologie, Lehrstuhl für GenetikUniversität München
  • Fritz Kaudewitz
    • Institut für Genetik und Mikrobiologie, Lehrstuhl für GenetikUniversität München
Article

DOI: 10.1007/BF00355403

Cite this article as:
Weiss-Brummer, B., Sakai, H. & Kaudewitz, F. Curr Genet (1987) 11: 295. doi:10.1007/BF00355403

Summary

The first case of a +1 “extrageneic” frameshift suppressor (MF1), mapping in the yeast mitochondrial 15S rRNA gene is reported. The suppressor was identified by genetic analyses in a leaky mitochondrial oxi1 frameshift mutant and the respective wild-type strain 777-3A of the yeast S. cerevisiae. This is in accordance with the finding that all mitochondrial frameshift mutants isolated from this strain tend to be leaky to a variable degree. MF1 does not suppress known nonsense mutations created by a direct basepair exchange in strain 777-3A. These mutants exhibit a non-leaky phenotype (Weiss-Brummer et al. 1984).

Key words

YeastMitochondrialFrameshift-Suppression15S rRNA

Copyright information

© Springer-Verlag 1987