Skeletal Radiology

, Volume 16, Issue 5, pp 360–363

Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

  • J. P. Devogelaer
  • J. Malghem
  • B. Maldague
  • C. Nagant de Deuxchaisnes
Articles

DOI: 10.1007/BF00350961

Cite this article as:
Devogelaer, J.P., Malghem, J., Maldague, B. et al. Skeletal Radiol (1987) 16: 360. doi:10.1007/BF00350961

Abstract

A 12-year-old female suffering fromosteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was striking. Furthermore, X-rays of the bones showed large, parallel radio-opaque striae, corresponding exactly to the periods of therapy. These were present in all metaphyses.

Key words

Bisphosphonate APD Osteogenesis imperfecta Dual photon absorptiometry Meta-physeal bands 

Copyright information

© International Skeletal Society 1987

Authors and Affiliations

  • J. P. Devogelaer
    • 1
  • J. Malghem
    • 2
  • B. Maldague
    • 2
  • C. Nagant de Deuxchaisnes
    • 1
  1. 1.Rheumatology Unit St-Luc University HospitalLouvain University in BrusselsBrusselsBelgium
  2. 2.Department of Radiology, St-Luc University HospitalLouvain University in BrusselsBrusselsBelgium
  3. 3.The Arthritis Unit, Department of Internal MedicineLouvain University in Brussels, St-Luc University HospitalBrusselsBelgium