Peptidergic innervation of the cerebral circulation. Role in subarachnoid hemorrhage in man
- Lars EdvinssonAffiliated withDepartment of Internal Medicine, University Hospital
- , Rolf UddmanAffiliated withDepartment of Otorhinolaryngology, University of Lund, Malmø General Hospital
- , Roar JuulAffiliated withDepartment of Neurosurgery, Regional University Hospital
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The perivascular fibers, sympathetic fibers (storing noradrenaline, neuropeptide Y), parasympathetic fibers (storing acetylcholine, vasoactive intestinal peptide, peptide histidine methionine and neuropeptide Y) and sensory fibers (storing tachykinins, calcitonin gene-related peptide) were traced using True Blue in monkey.
Tracing studies of the monkey middle-cerebral artery (MCA) innervation confirmed earlier studies in rats and cats, with superior cervical and trigeminal ganglia as main immunostaining areas, and contralateral involvement in the superior cervical and trigeninal ganglia. Sphenopalatine immunostaining was scarce.
The release of neuropeptides in the external jugular vein in humans in the postoperative course after subarachnoid hemorrhage, using radioimmunoassay, was correlated to hemodynamical changes (vasoconstriction) monitored with Doppler ultrasound on middle cerebral (MCA) and internal carotid arteries (ICA).
Neuropeptide Y-like immunoreactivity (NPY-LI) levels were increased compared to controls in patients with hemodynamic changes, and in some patients a relationship was found between velocities and NPY-LI.
Calcitonin gene-related peptide-LI levels were also increased in connection with vasospasm. In patients with MCA lesions a correlation of 0.61, p=0.0002 was found between hemodynamic index (V MCA/V ICA) and CGRP-LI.
The possible sympathetic and trigemino-cerebrovascular activation are discussed.
KeywordsCalcitonin gene-related peptide (CGRP) Doppler Neuropeptide Y (NPY) subarachnoid hemorhage (SAH)
- Peptidergic innervation of the cerebral circulation. Role in subarachnoid hemorrhage in man
Volume 13, Issue 4 , pp 265-272
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- Calcitonin gene-related peptide (CGRP)
- Neuropeptide Y (NPY)
- subarachnoid hemorhage (SAH)
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- Author Affiliations
- 1. Department of Internal Medicine, University Hospital, Lund, Sweden
- 2. Department of Otorhinolaryngology, University of Lund, Malmø General Hospital, Malmø, Sweden
- 3. Department of Neurosurgery, Regional University Hospital, Trondheim, Norway