Acta Neuropathologica

, Volume 85, Issue 4, pp 445–448

An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism

  • K. Hayashida
  • S. Oyanagi
  • Y. Mizutani
  • M. Yokochi
Short Original Communications

DOI: 10.1007/BF00334457

Cite this article as:
Hayashida, K., Oyanagi, S., Mizutani, Y. et al. Acta Neuropathol (1993) 85: 445. doi:10.1007/BF00334457

Summary

Neurons containing a central pale area which may possibly represent an early cytoplasmic change before Lewy body maturation were observed in the substantia nigra from a rare autopsy case of juvenile parkinsonism. Ultrastructurally, such neurons exhibited cytoplasmic swelling along with disappearance of the rough endoplasmic reticulum from the central part of the perikaryon. The pale central cytoplasm was replaced by numerous-cored vesicles, mitochondria, ribosomelike granules and a few Lewy body filaments. The relation of this central pale area to the pale body is discussed.

Key words

Juvenile parkinsonism Substantia nigra Central pale area Early Lewy body 

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • K. Hayashida
    • 1
  • S. Oyanagi
    • 1
  • Y. Mizutani
    • 2
  • M. Yokochi
    • 3
  1. 1.Department of Ultrastructural ResearchTokyo Institute of PsychiatryTokyoJapan
  2. 2.Department of NeurologyTokyo Metropolitan Matsuzawa HospitalTokyoJapan
  3. 3.Department of NeurologyTokyo Metropolitan Institute for NeuroscienceTokyoJapan
  4. 4.Department of NeuropsychiatryNagasaki University School of MedicineNagasakiJapan

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