Rheumatology International

, Volume 11, Issue 4, pp 187–189

The phagocyte oxidative metabolism function in ankylosing spondylitis

  • D. Wendling
  • J. M. Didier
  • D. A. Vuitton

DOI: 10.1007/BF00332560

Cite this article as:
Wendling, D., Didier, J.M. & Vuitton, D.A. Rheumatol Int (1991) 11: 187. doi:10.1007/BF00332560


The phagocyte oxydative metabolism function was measured using chemiluminescence in microamounts of whole blood in 15 ankylosing spondylitis (AS) patients (10 were B27 positive), and in 17 controls. It was obtained from cells at rest, and following stimulation (latex, zymosan, fMLP), with luminol and lucigenin as amplifiers. The maximal light intensity was significantly higher (P<0.01) in AS compared to the controls in resting cells as well as in those after stimulation. There was no difference between HLA-B27 positive or negative AS patients. The increase in oxidative metabolism of the phagocyte system in AS was more evident in the luminol dependent assay, suggesting an activation of the myeloperoxydase system.

Key words

Ankylosing spondylitis Phagocyte system Chemiluminescence 

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • D. Wendling
    • 1
  • J. M. Didier
    • 2
  • D. A. Vuitton
    • 2
  1. 1.Service de RhumatologieCentre Hospitalier Régional et UniversitaireBesançonFrance
  2. 2.Laboratoire Universitaire d'ImmunologieCentre Hospitalier Régional et UniversitaireBesançonFrance

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