, Volume 278, Issue 3, pp 625-628

Transformation of fibroblasts into endothelial cells during angiogenesis

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Light-and electron-microscopic autoradiography have been used to study fibroblast transformation into endothelial cells in the formation of new blood vessels during wound healing in rabbit ear chambers. When cultured fibroblasts labeled with tritium thymidine were transplanted autologously into the chambers, newly formed blood vessels contained endothelial cells labeled with tritium thymidine. This result suggests that fibroblasts play a pivotal role in angiogenesis, as progenitors of endothelial cells in newly formed blood vessels.