Cell and Tissue Research

, Volume 278, Issue 3, pp 625–628

Transformation of fibroblasts into endothelial cells during angiogenesis

  • Kazunori Kon
  • Takashi Fujiwara
Short Communications

DOI: 10.1007/BF00331383

Cite this article as:
Kon, K. & Fujiwara, T. Cell Tissue Res (1994) 278: 625. doi:10.1007/BF00331383


Light-and electron-microscopic autoradiography have been used to study fibroblast transformation into endothelial cells in the formation of new blood vessels during wound healing in rabbit ear chambers. When cultured fibroblasts labeled with tritium thymidine were transplanted autologously into the chambers, newly formed blood vessels contained endothelial cells labeled with tritium thymidine. This result suggests that fibroblasts play a pivotal role in angiogenesis, as progenitors of endothelial cells in newly formed blood vessels.

Key words

NeovascularizationEndothelial cellsFibroblastsCell transformationWound healingAutoradiographyRabbit

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Kazunori Kon
    • 1
  • Takashi Fujiwara
    • 2
  1. 1.Department of Medical Laboratory TechnologyEhime College of Health ScienceTobe, EhimeJapan
  2. 2.Laboratory Animal Center, School of MedicineEhime UniversityShigenobu, EhimeJapan