Molecular and General Genetics MGG

, Volume 201, Issue 3, pp 525–528

Role of Escherichia coli RecBC enzyme in SOS induction

  • Abdul M. Chaudhury
  • Gerald R. Smith

DOI: 10.1007/BF00331350

Cite this article as:
Chaudhury, A.M. & Smith, G.R. Molec Gen Genet (1985) 201: 525. doi:10.1007/BF00331350


Induction of the SOS genes is required for efficient repair of damaged DNA in Escherichia coli. SOS induction by nalidixic acid or oxolinic acid, two inhibitors of DNA gyrase, requires the RecBC enzyme of E. coli. We report here that the nuclease activity of RecBC enzyme is not needed for SOS induction by these agents. We suggest that the unwinding activity of RecBC enzyme produces single-stranded DNA which activates the RecA protein to stimulate LexA repressor cleavage and SOS induction.

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Abdul M. Chaudhury
    • 1
  • Gerald R. Smith
    • 1
  1. 1.Fred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.National Institute of Environmental Health SciencesResearch Triangle ParkUSA

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