Molecular and General Genetics MGG

, Volume 185, Issue 2, pp 352–355

Damage to DNA induces expression of the ruv gene of Escherichia coli

  • Claire E. Shurvinton
  • Robert G. Lloyd

DOI: 10.1007/BF00330811

Cite this article as:
Shurvinton, C.E. & Lloyd, R.G. Molec. Gen. Genet. (1982) 185: 352. doi:10.1007/BF00330811


Regulation of the ruv gene of E. coli was studied using phage Mud (Ap lac) to obtain a fusion of the lac genes to the ruv promoter. β-galactosidase synthesis in the ruv-lac fusion strain was induced by mitomycin C and other agents that damage DNA. The induction of β-galactosidase could be altered by mutations either in lexA or recA from which it is concluded that ruv is regulated by lexA repressor. A possible function of ruv in promoting cell recovery following damage to DNA is discussed.

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Claire E. Shurvinton
    • 1
  • Robert G. Lloyd
    • 1
  1. 1.Genetics DepartmentUniversity of NottinghamNottinghamEngland

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