Molecular and General Genetics MGG

, Volume 211, Issue 2, pp 272–281

The same configuration of Ty elements promotes different types and frequencies of rearrangements in different yeast strains

Authors

  • Susan Picologlou
    • Laboratory for Cell, Molecular, and Developmental Biology, Department of Biological SciencesUniversity of Illinois-Chicago
  • Mary E. Dicig
    • Laboratory for Cell, Molecular, and Developmental Biology, Department of Biological SciencesUniversity of Illinois-Chicago
  • Paula Kovarik
    • Laboratory for Cell, Molecular, and Developmental Biology, Department of Biological SciencesUniversity of Illinois-Chicago
  • Susan W. Liebman
    • Laboratory for Cell, Molecular, and Developmental Biology, Department of Biological SciencesUniversity of Illinois-Chicago
Article

DOI: 10.1007/BF00330604

Cite this article as:
Picologlou, S., Dicig, M.E., Kovarik, P. et al. Mol Gen Genet (1988) 211: 272. doi:10.1007/BF00330604

Summary

We examined Ty-mediated genomic rearrangements in three related mitotically dividing haploid yeast strains having the same configuration of Ty elements in the CYC1-sup4 interval of chromosome X. Surprisingly, quite different types and frequencies of rearrangements were found in the three strains. In one strain we found only Ty-mediated deletions, which occurred with a frequency of about 1×10-6. Another strain yielded similar deletions, but approximately one-third of these were accompanied by adjacent Ty-mediated inversions. A third strain was found to have an extremely high rate of inversion/reinversion between two of the three Ty elements. This rate was conservatively estimated to be 1.4±0.2×10-2 per cell per generation, which is at least 2 orders of magnitude higher than previously reported values for Ty-mediated rearrangements. These data provide evidence that local regions of the genome can, in some cases, be much more fluid than had been previously believed.

Key words

YeastTy elementsRecombination
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Copyright information

© Springer-Verlag 1988