, Volume 218, Issue 1, pp 87-92

Isolation of the facA (acetyl-Coenzyme A synthetase) and acuE (malate synthase) genes of Aspergillus nidulans

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Acetate inducible genes of Aspergillus nidulans were cloned via differential hybridization to cDNA probes. Using transformation of mutant strains the genes were identified as facA (acetyl-Coenzyme A synthetase) and acuE (malate synthase). The levels of RNA encoded by these genes were shown to be acetate inducible and subject to carbon catabolite repression. Induction is abolished in a facB mutant and carbon catabolite repression is relieved in a creA mutant.

Communicated by W. Gajewski