Summary
All linear measurements employed for evaluation of brain atrophy, were performed on 148 computed tomograms of patients aged 28 to 84 without evidence of any nervous system disorder. These included size of lateral, third and fourth ventricles, width of the Sylvian and frontal interhemispheric fissures and cortical sulci and size of the pre-pontine cistern. Various parameters indicated decrease in brain mass with age. Since the atrophic process is a diffuse phenomenon, integration of several measurements evaluating separate brain regions was made. The bicaudate ratio and the Sylvian fissure ratio (representing both central and cortical atrophy) were cominbed arithmetically, resulting in a correlation of 0.6390 with age (P<0.0005). With a computed canonical correlation analysis; a formula was obtained which combined measurements of the lateral and third ventricles, the Sylvian fissure and the pre-pontine cistern. This formula yielded a correlation of 0.67795 (P<0.0005). These linear measurements will allow simple and reliable assessment of reduction in brain volume during the normal aging process and in disorders accompanied by brain atrophy.
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References
Carlen PL, Wilkinsin DA (1980) Alcoholic brain damage and reversible deficit. Acta Psychiatr Scand [Suppl] 286:103–118
Davidoff LM, Dyke CG (1951) The normal encephalogram, 3rd ed. Lea and Febiger, Philadelphia, p 73
Sabattini L (1982) Evaluation and measurement of the normal ventricular and subarachnoid spaces by CT. Neuroradiology 23:1–5
Pentlow KS, Rottenberg DA, Deck MDF (1978) Partial volume summation: a simple approach to ventricular volume determination from CT. Neuroradiology 16:130–132
Rottenberg DA, Pentlow KS, Deck MDF, Allen JC (1978) Determination of ventricular volume following metrizamide CT ventriculography. Neuroradiology 16:136–139
Jacoby RJ, Levy R, Dawson JM (1980) Computed tomography in the elderly: I. The normal population. Br J Psychiatry 136: 249–255
Zeumer H, Hacke W, Hartwich P (1982) A quantitative approach to measuring the cerebrospinal fluid space with CT. Neuroradiology 22:193–197
Gyldensted C, Kosteljanetz M (1975) Measurements of the normal hemispheric sulci with computer tomography: a preliminary study on 44 adults. Neuroradiology 10:147–149
Huang G (1977) Age and sex dependence of the size of normal ventricles on computed tomography. Neuroradiology 14: 201–204
Gyldensted C, Kostelanetz M (1976) Measurements of the normal ventricular system with computer tomography of the brain: a preliminary study on 44 adults. Neuroradiology 10: 205–213
Fox JH, Topel JL, Huckman MS (1975) Use of computerized tomography in senile dementia. J Neurol Neurosurg Psychiatry 38:948–953
Meese W, Kluge W, Grumme T, Hopfenmuller W (1980) CT evaluation of the CSF spaces of healthy persons. Neuroradiology 19:131–136
Synek V, Reuben JR (1976) The ventricular brain ratio using plasmetric measurement of EMI scans. Br J Radiol 49: 233–237
Nie NH, Hadlai Hall C, Jenkins JG, Steinbrenner K, Bent DH (1975) Statistical package for the social sciences, 2 nd ed, Chapter 25, McGraw-Hill, New York
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Gomori, J.M., Steiner, I., Melamed, E. et al. The assessment of changes in brain volume using combined linear measurements. Neuroradiology 26, 21–24 (1984). https://doi.org/10.1007/BF00328197
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DOI: https://doi.org/10.1007/BF00328197