Surgery Today

, Volume 22, Issue 1, pp 15–18

Changes in the productivity of cytokines and active-oxygen in peripheral blood cells following surgery

  • Yasuhito Abe
  • Masazumi Miyake
  • Atsushi Horiuchi
  • Kaori Kumori
  • Shigeru Kimura
Original Articles

DOI: 10.1007/BF00326119

Cite this article as:
Abe, Y., Miyake, M., Horiuchi, A. et al. Surg Today (1992) 22: 15. doi:10.1007/BF00326119
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Abstract

An investigation was carried out on the productivity of cytokines and active-oxygen by peripheral blood cells during the pre- and post-operative periods. While the preoperative production of tumor necrosis factor (TNF) and interleukin-lα (IL-1α) was elevated, that of lymphotoxin (LT) and interferon-γ (IFN-γ) were slightly suppressed. In the postoperative period the peak TNF and IL-1α and active-oxygen productivity was elevated, while LT and IFN-γ productivity was suppressed in patients with an intraoperative bleeding volume of more than 1,000 ml compared to those with that of less than 1,000 ml. Thus, stress stimulates the TNF and IL-1α and active-oxygen producing system, that is, the macrophage-neutrophil system, and suppresses the LT and IFN-γ system, being, the inflammatory helper T cell system, in the early postoperative period.

Key words

TNF IL-1α lymphotoxin INF-γ activeoxygen surgical stress 

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Yasuhito Abe
    • 1
  • Masazumi Miyake
    • 1
  • Atsushi Horiuchi
    • 1
  • Kaori Kumori
    • 1
  • Shigeru Kimura
    • 1
  1. 1.The Second Department of SurgeryEhime University School of MedicineEhimeJapan

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