Anatomy and Embryology

, Volume 180, Issue 1, pp 29–35

Distribution of the neural crest cells in the heart of birds: a three dimensional analysis

  • Hiroshi Sumida
  • Naotaka Akimoto
  • Harukazu Nakamura
Original Articles

DOI: 10.1007/BF00321897

Cite this article as:
Sumida, H., Akimoto, N. & Nakamura, H. Anat Embryol (1989) 180: 29. doi:10.1007/BF00321897


The distribution of neural crest derived cells (NC) in the heart of quail-chick chimeric embryos was analyzed three-dimensionally after computer reconstruction. During the division of the truncus arteriosus into the aorta and the pulmonary trunk, ventral and dorsal columns of NC-derived cells were found in the truncal swellings. These columns were elongations from the aorticopulmonary (AP) septum. The dorsal column extended more proximally than did the ventral column. Around hatching, NC-derived cells located between the proximal aorta and the pulmonary trunk, differentiated into cartilage and connective tissue. They formed a part of the cardiac skeleton. A small number of NC-derived cells were scattered in the cusps of the arterial valves. Cells derived from the right NC were located around the aorta and the right arch arteries but not around the distal pulmonary trunk and the left arch arteries. At the proximal level, cells derived from the rigth NC were located in both the dorsal and ventral columns. These results suggest that the AP septum is mainly formed by NC-derived cells, right and left NC cells migrating into assigned areas in the heart. Location of two columns of NC-derived cells may support a translocation hypothesis for the AP septum during truncal division.

Key word

Neural crest Heart Quail-chick chimera Computer reconstruction 

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Hiroshi Sumida
    • 1
  • Naotaka Akimoto
    • 1
  • Harukazu Nakamura
    • 2
  1. 1.Department of Geneticopathology, Research Institute for Nuclear Medicine and BiologyHiroshima UniversityHiroshimaJapan
  2. 2.Department of Anatomy, School of MedicineHiroshima UniversityHiroshimaJapan
  3. 3.Department of BiologyKyoto Prefectural University of MedicineKyotoJapan

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