Cell and Tissue Research

, Volume 282, Issue 3, pp 455–461

Selective binding and transcytosis of Ulex europaeus 1 lectin by mouse Peyer's patch M-cells in vivo

  • M. Ann Clark
  • Mark A. Jepson
  • Nicholas L. Simmons
  • Barry H. Hirst
Article

DOI: 10.1007/BF00318877

Cite this article as:
Clark, M.A., Jepson, M.A., Simmons, N.L. et al. Cell Tissue Res (1995) 282: 455. doi:10.1007/BF00318877

Abstract

The in vivo interaction of the lectin Ulex europaeus agglutinin 1 with mouse Peyer's patch follicle-associated epithelial cells was studied in the mouse Peyer's patch gut loop model by immunofluorescence and electron microscopy. The lectin targets to mouse Peyer's patch M-cells and is rapidly endocytosed and transcytosed. These processes are accompanied by morphological changes in the M-cell microvilli and by redistribution of polymerised actin. The demonstration of selective binding and uptake of a lectin by intestinal M-cells in vivo suggests that M-cell-specific surface glycoconjugates might act as receptors for the selective adhesion/uptake of microorganisms.

Key words

Lectin Ulex europaeusPeyer's patches Follicle-associated epithelium M-cells Transcytosis In vivo Mouse (BALB/c) 

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. Ann Clark
    • 1
    • 2
  • Mark A. Jepson
    • 1
    • 2
  • Nicholas L. Simmons
    • 1
    • 2
  • Barry H. Hirst
    • 1
    • 2
  1. 1.Gastrointestinal Drug Delivery Research CentreUniversity of Newcastle upon Tyne, Medical SchoolNewcastle upon TyneUK
  2. 2.Department of Physiological SciencesUniversity of Newcastle upon Tyne, Medical SchoolNewcastle upon TyneUK

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