Anatomy and Embryology

, Volume 173, Issue 2, pp 149–155

Ontogeny of renin immunoreactive cells in the human kidney

  • M. R. Celio
  • P. Groscurth
  • T. Inagami
Article

DOI: 10.1007/BF00316297

Cite this article as:
Celio, M.R., Groscurth, P. & Inagami, T. Anat Embryol (1985) 173: 149. doi:10.1007/BF00316297

Summary

We studied the time of appearance of renin-immunoreactive cells in prenatal human kidneys by immunohistochemistry and transmission electron microscopy (TEM). Renin immunoreactivity was detectable as early as the 5th or 6th gestational week in the mesonephros and appeared at 8 weeks of gestation in the metanephros. In a 8 week old embryo “renin granules” were seen by TEM in the juxtaglomerular epithelioid granular cells of metanephric tissue. In the embryos delivered by prostaglandin-induced abortion, granular renin immunoreactivity was also present in the cells of the proximal convoluted tubule.

Our results support the contention that the renin-angiotensin system is active during fetal life and indicates a role for renin even during the embryonic period. In addition, they document a morphologically detectable effect of prostaglandins on the distribution of renin in the kidney.

Key words

Renin-angiotensin system Human kidney Epithelioid granular cells Prostaglandins 

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • M. R. Celio
    • 1
  • P. Groscurth
    • 1
  • T. Inagami
    • 2
  1. 1.Anatomisches Institut der Universität ZürichZürichSwitzerland
  2. 2.Dept. of BiochemistryVanderbilt School of MedicineNashvilleUSA