Ivermectin binds avidly to plasma proteins
- Cite this article as:
- Klotz, U., Ogbuokiri, J.E. & Okonkwo, P.O. Eur J Clin Pharmacol (1990) 39: 607. doi:10.1007/BF00316107
Human pharmacokinetic data on the new antiparasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2±4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.