European Journal of Clinical Pharmacology

, Volume 39, Issue 6, pp 607–608

Ivermectin binds avidly to plasma proteins

  • U. Klotz
  • J. E. Ogbuokiri
  • P. O. Okonkwo
Short Communications

DOI: 10.1007/BF00316107

Cite this article as:
Klotz, U., Ogbuokiri, J.E. & Okonkwo, P.O. Eur J Clin Pharmacol (1990) 39: 607. doi:10.1007/BF00316107

Summary

Human pharmacokinetic data on the new antiparasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2±4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.

Key words

ivermectinpharmacokineticsplasma protein binding

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • U. Klotz
    • 1
  • J. E. Ogbuokiri
    • 2
  • P. O. Okonkwo
    • 2
  1. 1.Dr. Margarete-Fischer-Bosch Institut für Klinische PharmakologieStuttgartFRG
  2. 2.Department of Pharmacology and TherapeuticsUniversity of Nigeria Teaching HospitalEnuguNigeria
  3. 3.College of PharmacyKing Saud UniversityRiyadhSaudi Arabia