Acta Neuropathologica

, Volume 90, Issue 4, pp 366–374

Mitochondrial abnormalities in human immunodeficiency virus-associated myopathy

  • Susan Morgello
  • David Wolfe
  • Emilie Godfrey
  • Rikki Feinstein
  • Michele Tagliati
  • David M. Simpson
Regular Paper

DOI: 10.1007/BF00315010

Cite this article as:
Morgello, S., Wolfe, D., Godfrey, E. et al. Acta Neuropathol (1995) 90: 366. doi:10.1007/BF00315010

Abstract

There is controversy as to whether zidovudine (ZDV) induces a mitochondrial myopathy that is distinguishable from human immunodeficiency virus (HIV)-associated myopathy in ZDV-naive patients. Mitochondrial abnormalities were evaluated in skeletal muscle obtained from 18 HIV-positive, ZDV-exposed patients, and 9 who were drug naive. All patients had clinical myopathy, and underwent neuromuscular evaluation with information recorded on timing and dosage of ZDV. All underwent muscle biopsies and samples were examined without knowledge of clinical history of ZDV status. Biopsy samples were evaluated by light and electron microscopy. Mitochondrial abnormalities were seen in ZDV-treated and-naive groups, and did not correlate with ZDV exposure or cumulative ZDV dosage. Mitochondrial abnormalities displayed significant correlation with the presence and severity of myofiber degeneration on biopsy, regardless of ZDV status. As mitochondrial abnormalities reflect myofiber degeneration, present in both patient groups, they may not be used as evidence of primary mitochondrial dysfunction. The etiology of myofiber degeneration in patients with HIV infection, whether ZDV-exposed ornaive, remains unclear.

Key words

Human immunodeficiency virusMyopathyMitochondriaZidovudine

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Susan Morgello
    • 1
  • David Wolfe
    • 1
  • Emilie Godfrey
    • 2
  • Rikki Feinstein
    • 2
  • Michele Tagliati
    • 2
  • David M. Simpson
    • 2
  1. 1.Department of Pathology (Division of Neuropathology)Mount Sinai Medical CenterNew York CityUSA
  2. 2.Department of NeurologyMount Sinai Medical CenterNew York CityUSA