Short Communications

Journal of Neurology

, Volume 233, Issue 3, pp 178-179

First online:

Tourette syndrome: successful treatment with clonidine and oxycodone

  • R. SandykAffiliated withUniversity of Arizona

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A 15-year-old boy with Tourette's syndrome exhibited severe involuntary self-mutilatory behavior. While clonidine effectively controlled the motor and phonic tics, it failed to ameliorate the self-mutilatory behavior. Administration of oxycodone (50 mg/day) combined with clonidine produced a dramatic reduction in the frequency and severity of the self-mutilatory acts within 12 h. This report indicates that disturbances in the functional interplay between the noradrenergic and opiatergic systems may be important in the pathophysiology of Tourette's syndrome.

Key words

Tourette's syndrome Self-mutilatory behavior Clonidine Oxycodone