Journal of Neurology

, Volume 233, Issue 3, pp 178–179

Tourette syndrome: successful treatment with clonidine and oxycodone

  • R. Sandyk
Short Communications

DOI: 10.1007/BF00314429

Cite this article as:
Sandyk, R. J Neurol (1986) 233: 178. doi:10.1007/BF00314429


A 15-year-old boy with Tourette's syndrome exhibited severe involuntary self-mutilatory behavior. While clonidine effectively controlled the motor and phonic tics, it failed to ameliorate the self-mutilatory behavior. Administration of oxycodone (50 mg/day) combined with clonidine produced a dramatic reduction in the frequency and severity of the self-mutilatory acts within 12 h. This report indicates that disturbances in the functional interplay between the noradrenergic and opiatergic systems may be important in the pathophysiology of Tourette's syndrome.

Key words

Tourette's syndromeSelf-mutilatory behaviorClonidineOxycodone

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • R. Sandyk
    • 1
  1. 1.University of ArizonaTucson
  2. 2.Department of Internal Medicine (Neurology)Health Sciences CenterTucsonUSA