Journal of Neurology

, Volume 235, Issue 3, pp 168–170

Primidone and essential tremor


  • S. Seyfert
    • Neurologische KlinikFreie Universität Berlin
  • A. Honé
    • Neurologische KlinikFreie Universität Berlin
  • G. Holl
    • Abteilung für Klinische Neurophysiologie, Klinikum SteglitzFreie Universität Berlin
Short Communications

DOI: 10.1007/BF00314310

Cite this article as:
Seyfert, S., Honé, A. & Holl, G. J Neurol (1988) 235: 168. doi:10.1007/BF00314310


To clarify whether primidone itself, and not only its metabolite phenobarbitone, suppresses essential tremor, the effect of a high single dose of primidone was tested. Of 11 patients, 8 showed a reduction of their tremor by 54%–69% for up to 28h. The serum concentration of primidone was as expected, whereas those of the metabolites phenyl-ethylmalonamide and phenobarbitone were very low. The tremor suppression can thus be considered to be an effect of primidone. Three of the 11 patients did not show a reduction of tremor.

Key words

PrimidoneEssential tremor

Copyright information

© Springer-Verlag 1988