Journal of Neurology

, Volume 235, Issue 8, pp 466–471

Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease

Authors

  • P. Foley
    • Department of BiochemistryImperial College of Science and Technology
  • H. F. Bradford
    • Department of BiochemistryImperial College of Science and Technology
  • M. Docherty
    • Department of BiochemistryImperial College of Science and Technology
  • H. Fillit
    • The Rockefeller University
  • V. N. Luine
    • The Rockefeller University
  • B. McEwen
    • The Rockefeller University
  • G. Bucht
    • Department of Geriatric MedicineUniversity of Umea
  • B. Winblad
    • Department of Geriatric MedicineKarolinska Institute
  • J. Hardy
    • Department of BiochemistrySt. Mary's Hospital Medical School
Original Investigations

DOI: 10.1007/BF00314249

Cite this article as:
Foley, P., Bradford, H.F., Docherty, M. et al. J Neurol (1988) 235: 466. doi:10.1007/BF00314249

Summary

A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

Key words

Alzheimer's diseaseImmunolysisCholinergic neuronesSynaptosomes

Copyright information

© Springer-Verlag 1988