Journal of Neurology

, Volume 235, Issue 8, pp 466–471

Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease

  • P. Foley
  • H. F. Bradford
  • M. Docherty
  • H. Fillit
  • V. N. Luine
  • B. McEwen
  • G. Bucht
  • B. Winblad
  • J. Hardy
Original Investigations

DOI: 10.1007/BF00314249

Cite this article as:
Foley, P., Bradford, H.F., Docherty, M. et al. J Neurol (1988) 235: 466. doi:10.1007/BF00314249

Summary

A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

Key words

Alzheimer's diseaseImmunolysisCholinergic neuronesSynaptosomes

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • P. Foley
    • 1
  • H. F. Bradford
    • 1
  • M. Docherty
    • 1
  • H. Fillit
    • 2
  • V. N. Luine
    • 2
  • B. McEwen
    • 2
  • G. Bucht
    • 3
  • B. Winblad
    • 4
  • J. Hardy
    • 5
  1. 1.Department of BiochemistryImperial College of Science and TechnologyLondonUK
  2. 2.The Rockefeller UniversityNew YorkUSA
  3. 3.Department of Geriatric MedicineUniversity of UmeaUmeaSweden
  4. 4.Department of Geriatric MedicineKarolinska InstituteStockholmSweden
  5. 5.Department of BiochemistrySt. Mary's Hospital Medical SchoolLondonUK