Journal of Neurology

, Volume 234, Issue 2, pp 94–96

Depression and parkinson's disease: possible role of serotonergic mechanisms

  • V. S. Kostić
  • B. M. Djuričić
  • N. Čovičković-Šternić
  • L. Bumbaširević
  • M. Nikolić
  • B. B. Mršulja
Original Investigations

DOI: 10.1007/BF00314109

Cite this article as:
Kostić, V.S., Djuričić, B.M., Čovičković-Šternić, N. et al. J Neurol (1987) 234: 94. doi:10.1007/BF00314109

Summary

Depression is frequently encountered in Parkinson's disease and was seen to occur in 14 of 26 patients studied. The levels of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of serotonin (5-HT), in CSF samples of the patients were significantly lower than in those of controls. However, within the group of patients the levels of 5-HIAA in CSF samples were significantly lower in the depressive subgroup compared with the non-depressive patients. Moreover, no correlation was recorded between motor disability and depression. The results indicate that disturbed 5-HT metabolism may possibly play a role in Parkinson's disease as a predisposing factor in the development of depression.

Key words

Parkinson's diseaseDepressionHuman cerebrospinal fluid5-Hydroxyindoleacetic acid

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • V. S. Kostić
    • 1
  • B. M. Djuričić
    • 2
  • N. Čovičković-Šternić
    • 1
  • L. Bumbaširević
    • 1
  • M. Nikolić
    • 1
  • B. B. Mršulja
    • 2
  1. 1.Department of NeurologySchool of MedicineBelgradeYugoslavia
  2. 2.Institute of BiochemistrySchool of MedicineBelgradeYugoslavia