Journal of Neurology

, Volume 233, Issue 4, pp 237–241

Polymorphonuclear pleocytosis in the cerebrospinal fluid during chemotherapy for tuberculous meningitis

  • R. Teoh
  • Sister Gabriel O'Mahony
  • V. T. F. Yeung
Original Investigations

DOI: 10.1007/BF00314027

Cite this article as:
Teoh, R., O'Mahony, S.G. & Yeung, V.T.F. J Neurol (1986) 233: 237. doi:10.1007/BF00314027


Five patients on chemotherapy for tuberculous meningitis developed sudden and unexpected cerebrospinal fluid pleocytosis consisting predominantly of polymorphonuclear leucocytes. The cellular changes, which developed 4–108 days after starting treatment, were not accompanied by an alteration in the clinical state and disappeared within a week whether or not an additional antibiotic was prescribed. Though the cause is uncertain, possible mechanisms are discussed. We are prompted to report these cases because the cytological changes are not well recognised and may cause difficulties in management.

Key words

TB meningitis Cerebrospinal fluid Pleocytosis 

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • R. Teoh
    • 1
  • Sister Gabriel O'Mahony
    • 2
  • V. T. F. Yeung
    • 1
  1. 1.Department of MedicineThe Chinese University of Hong KongChina
  2. 2.The Ruttonjee SanatoriumHong Kong
  3. 3.Department of MedicinePrince of Wales HospitalHong Kong

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