Current Genetics

, Volume 28, Issue 1, pp 32–38

Schizosaccharomyces pombe pac2+ controls the onset of sexual development via a pathway independent of the cAMP cascade

  • Hirofumi Kunitomo
  • Asako Sugimoto
  • Masayuki Yamamoto
  • Caroline R. M. Wilkinson
Original Paper

DOI: 10.1007/BF00311879

Cite this article as:
Kunitomo, H., Sugimoto, A., Yamamoto, M. et al. Curr Genet (1995) 28: 32. doi:10.1007/BF00311879

Abstract

The Schizosaccharomyces pombe pac2 gene encodes a protein of 235 amino acids not similar to any protein of known function. Cells over-expressing pac2 were poor in mating and sporulation. Expression of ste11, which encodes a key transcription factor for sexual development, was not inducible by nitrogen starvation in these cells. Cells defective in pac2 could express ste11 and enter sexual development under incomplete starvation conditions. Although expression of ste11 is regulated primarily by the cAMP cascade, genetic analysis indicated that this cascade and pac2 can partially compensate for each other in the regulation of sexual development, and that neither of them is epistatic over the other. Thus, Pac2 appears to control ste11 expression via a signaling pathway independent of the cAMP cascade.

Key words

Mating and meiosiscAMPProtein kinase AFission yeast

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Hirofumi Kunitomo
    • 1
  • Asako Sugimoto
    • 1
  • Masayuki Yamamoto
    • 1
  • Caroline R. M. Wilkinson
    • 2
  1. 1.Department of Biophysics and Biochemistry, School of ScienceUniversity of TokyoTokyoJapan
  2. 2.ICRF Epigenetic Laboratory, Institute of Cell and Molecular BiologyUniversity of EdinburghEdinburghUK
  3. 3.Department of BiochemistryUniversity of WisconsinMadisonUSA