Surgery Today

, Volume 26, Issue 3, pp 213–216

Cervical Castleman's disease associated with benign M-proteinemia: Report of a case


  • Makoto Komatsu
    • Department of SurgeryFujimi-kogen Hospital
  • Takashi Ehara
    • Department of PathologyShinshu University School of Medicine
  • Takai Kuroda
    • Department of SurgeryShinshu University School of Medicine
Case Reports

DOI: 10.1007/BF00311511

Cite this article as:
Komatsu, M., Ehara, T. & Kuroda, T. Surg Today (1996) 26: 213. doi:10.1007/BF00311511


We report the unusual case of a 77-year-old man with cervical Castleman's disease associated with benign M-proteinemia. The patient was found to have an anterior cervical tumor during a follow-up examination after surgery for early gastric cancer, at which time blood biochemistry tests revealed M-proteinemia at the position of β-globulin with a high level of IgG and low levels of IgA and IgM. Serum protein immunoelectrophoresis revealed M-protein consisting of the IgG-k chain, and urine protein immunoelectrophoresis demonstrated Bence Jones protein consisting of the chain. No abnormalities were noted in bone marrow aspiration or bone scintigram. The results of imaging and fine-needle aspiration biopsy of the tumor led to a preoperative diagnosis of cervical malignant lymphoma with suspected M-proteinemia derived from this disease, and resection of the anterior cervical tumor with bilateral neck dissection was performed. Histopathological examination subsequently demonstrated four mixed-type tumors of Castleman's disease. The pathogenesis of Castleman's disease remains unknown; however, we speculate that the complication of benign M-proteinemia in this patient was not incidental, but caused by an underlying immunological abnormality of the B cells.

Key Words

Castleman's diseasebenign M-proteinemiaimmunological abnormality of the B cells

Copyright information

© Springer-Verlag 1996