Acta Neuropathologica

, Volume 84, Issue 2, pp 157–162

Vimentin immunoreactivity in normal and pathological human brain tissue

  • T. Yamada
  • T. Kawamata
  • D. G. Walker
  • P. L. McGeer
Regular Papers

DOI: 10.1007/BF00311389

Cite this article as:
Yamada, T., Kawamata, T., Walker, D.G. et al. Acta Neuropathol (1992) 84: 157. doi:10.1007/BF00311389

Summary

Vimentin immunoreactivity was examined in brain tissues from non-neurological and various human central nervous system disease cases. In all brain tissues examined, vimentin immunoreactivity was intensely positive in ependymal cells and subpial tissues, and weakly positive in some capillaries and some white matter astrocytes. In affected areas of Alzheimer's disease (AD), Pick's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and cerebral infarction cases, numerous intensely vimentin-immunopositive astrocytes of both protoplasmic and fibrous morphology were demonstrated. A few such astrocytes were also observed in Parkinson's disease and progressive supranuclear palsy. ALS, MS and infarction brains also had numerous, strongly vimentin-positive, round and fat-laden microglia/macrophages. In AD and ALS, a few reactive microglia with irregularly enlarged shapes were vimentin positive. In AD, they were almost exclusively related to senile plaques.

Key words

VimentinAstrocyteMicrogliaMacrophageAlzheimer's disease

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • T. Yamada
    • 1
    • 2
  • T. Kawamata
    • 1
    • 2
  • D. G. Walker
    • 1
    • 2
  • P. L. McGeer
    • 1
    • 2
  1. 1.Kinsmen Laboratory of Neurological ResearchUniversity of British ColumbiaVancouverCanada
  2. 2.the Neurodegenerative Diseases CentreUniversity of British ColumbiaVancouverCanada
  3. 3.University of B. C.VancouverCanada