Current Genetics

, Volume 27, Issue 5, pp 393–403

Genetic and biochemical dissection of the mitochondrial protein-import machinery

  • M. Kübrich
  • K. Dietmeier
  • N. Pfanner
Review

DOI: 10.1007/BF00311207

Cite this article as:
Kübrich, M., Dietmeier, K. & Pfanner, N. Curr Genet (1995) 27: 393. doi:10.1007/BF00311207

Abstract

Mitochondria import most of their proteins from the cytosol. A multi-subunit machinery accomplishes the translocation of precursor polypeptides into across the two mitochondrial membranes. Within recent years more than 20 different proteins have been identified which are involved in mitochondrial protein import. This review summarizes the successful genetic and biochemical approaches that led to the identification of these transport and folding components. The identification and functional characterization of the components can be seen as a paradigm for the molecular analysis of a complex biological process by a combination of biochemical and genetic procedures.

Key words

Mitochondria Protein sorting MOM proteins MIM proteins Heat-shock proteins 

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. Kübrich
    • 1
  • K. Dietmeier
    • 1
  • N. Pfanner
    • 1
  1. 1.Biochemisches InstitutUniversität FreiburgFreiburgGermany

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