Calcified Tissue International

, Volume 55, Issue 1, pp 71–73

Comparison of the acute biological action of injectable salmon calcitonin and an injectable and oral calcitonin analogue

  • J. P. Devogelaer
  • M. Azria
  • M. Attinger
  • G. Abbiati
  • C. Castiglioni
  • C. Nagant de Deuxchaisnes
Rapid Communications

DOI: 10.1007/BF00310172

Cite this article as:
Devogelaer, J.P., Azria, M., Attinger, M. et al. Calcif Tissue Int (1994) 55: 71. doi:10.1007/BF00310172

Summary

In most countries, calcitonin is available in the form of injections, and less frequently as an intranasal spray. An oral route of administration should improve compliance. In a preliminary feasibility study, we have compared the acute biological action of injectable salmon calcitonin (50 IU), with the injectable calcitonin analogue ASC 710 (0.2 mg) and oral ASC 710 (20 mg) in 6 patients suffering from active Paget's disease of bone. The intensity and duration of the biological response were not significantly different in the 3 modes of therapy. In conclusion, the oral calcitonin analogue ASC 710 possesses an antiresorbing activity in Paget's disease comparable to that of an injection of salmon calcitonin which demonstrates that it can cross the intestinal barrier.

Key words

Calcitonin oral analogue Paget's disease 

Copyright information

© Springer-Verlag New York Inc 1994

Authors and Affiliations

  • J. P. Devogelaer
    • 1
  • M. Azria
    • 2
  • M. Attinger
    • 2
  • G. Abbiati
    • 3
  • C. Castiglioni
    • 3
  • C. Nagant de Deuxchaisnes
    • 1
  1. 1.Department of RheumatologySt-Luc University HospitalBrusselsBelgium
  2. 2.Preclinical ResearchSandoz Pharma LtdBasleSwitzerland
  3. 3.LPB Istituto FarmaceuticoCinisello BalsamoItaly

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