Acta Neuropathologica

, Volume 89, Issue 3, pp 248–257

Differential expression of cell adhesion molecules (CAM), neural CAM and epithelial cadherin in ependymomas and choroid plexus tumors

  • Dominique Figarella-Branger
  • Hubert Lepidi
  • Christian Poncet
  • Danielle Gambarelli
  • Nicole Bianco
  • Geneviève Rougon
  • Jean-François Pellissier
Regular Paper

DOI: 10.1007/BF00309340

Cite this article as:
Figarella-Branger, D., Lepidi, H., Poncet, C. et al. Acta Neuropathol (1995) 89: 248. doi:10.1007/BF00309340

Abstract

A series of frozen specimens of 18 ependymomas and 7 choroid plexus tumors were examined for their expression of cell adhesion molecules, such as neural cell adhesion molecule (NCAM), its polysialylated isoforms (PSA NCAM), and epithelial (E-) cadherin, and of intermediate filament proteins, such as glial fibrillary acidic protein (GFAP) and cytokeratin, using various monoclonal and polyclonal antibodies. Normal choroid plexus and ependyma were taken as controls. Anti-E-cadherin immunoreactivity was observed on the basolateral part of most adult choroid plexus and benign choroid plexus papilloma cells. However, a small number of atypical papillomas and carcinoma cells showed anti- E-cadherin immunoreactivity throughout their cell surface membrane. NCAM were not expressed by adult choroid plexus and benign papilloma cells. Only a few cells expressed NCAM and PSA NCAM in developing choroid plexus, atypical papillomas and carcinomas. Cytokeratin expression was always observed in choroid plexus and their tumors; GFAP expression was variable from case to case. In contrast, ependymal cells and their tumors never expressed E-cadherin but strongly expressed NCAM. PSA NCAM was found in ependymomas exhibiting anaplastic features. All ependymomas strongly expressed GFAP and a few demonstrated slight expression of cytokeratin. These data suggest that, besides GFAP and cytokeratin, NCAM and E-cadherin are of potential diagnostic value in distinguishing choroid plexus tumors from ependymomas. E-cadherin and NCAM may play a role in the functional organization of normal choroid plexus and ependyma, respectively. In particular, incomplete or irregular anti-E-cadherin expression in choroid plexus tumors and PSA NCAM immunoreativity in ependymomas and choroid plexus tumors correlates with the emergence of anaplastic histological features.

Key words

Neural cell adhesion moleculeEpithelial cadherinEpendymaChoroid plexusCentral nervous system tumors

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Dominique Figarella-Branger
    • 1
    • 2
  • Hubert Lepidi
    • 1
  • Christian Poncet
    • 1
  • Danielle Gambarelli
    • 1
  • Nicole Bianco
    • 1
  • Geneviève Rougon
    • 2
  • Jean-François Pellissier
    • 1
  1. 1.Laboratoire de Biopathologie Nerveuse et MusculaireFaculté de MédecineMarseilleFrance
  2. 2.Laboratoire de Génétique et de Physiologie du Développement, CNRS case 907Université de LuminyMarseilleFrance