Surgery Today

, Volume 23, Issue 3, pp 260–264

Juvenile gigantomastia: Report of a case

Authors

  • Tadaoki Morimoto
    • The School of Medical ScienceUniversity of Tokushima
  • Kansei Komaki
    • The School of Medical ScienceUniversity of Tokushima
  • Toshiaki Mori
    • The School of Medical ScienceUniversity of Tokushima
  • Mitsunori Sasa
    • The School of Medical ScienceUniversity of Tokushima
  • Hitoshi Miki
    • The School of Medical ScienceUniversity of Tokushima
  • Hiroyuki Inoue
    • The School of Medical ScienceUniversity of Tokushima
  • Yasumasa Monden
    • the Second Department of SurgeryUniversity of Tokushima
  • Hideki Nakanishi
    • the Department of Plastic Surgery, School of MedicineUniversity of Tokushima
Case Reports

DOI: 10.1007/BF00309238

Cite this article as:
Morimoto, T., Komaki, K., Mori, T. et al. Surg Today (1993) 23: 260. doi:10.1007/BF00309238

Abstract

Juvenile gigantomastia in a 12-year-old girl was treated by a bilateral reduction mammoplasty with free transplantation of the areolae and nipples and the removal of 3,980 g of breast tissue. Regrowth of the residual breast tissue has been suppressed by the administration of tamoxifen, an antiestrogen drug, since the surgery. This case was positive for estrogen receptors (ER) by the dextran-coated charcoal method, while tissue staining for ER and estradiol resulted in a darker staining of the epithelial contents, especially of fibroadenoma-like nodules, using an immunocytochemical assay. It is thus suggested that the etiology of this disease might be related to a local hypersensitivity to estrogen.

Key Words

juvenile gigantomastiavirginal macromastiajuvenile breast hypertrophyhormone receptors
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Copyright information

© Springer-Verlag 1993