Theoretical and Applied Genetics

, Volume 70, Issue 5, pp 491-496

First online:

A FORTRAN program for the calculation and analysis of two-locus linkage disequilibrium coefficients

  • W. C. BlackIVAffiliated withDepartment of Entomology, Iowa State University
  • , E. S. KrafsurAffiliated withDepartment of Entomology, Iowa State University

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A FORTRAN program was written that calculates composite linkage disequilibrium coefficients from genotypic data. Chi-square tests determine whether coefficients calculated for allele and locus pairs are significantly greater than zero. A subroutine is provided that partitions the variance in linkage disequilibrium into within- and between-subpopulation components. Output obtained from analysis of allozyme data collected from natural subpopulations of the house fly (Musca domestica L.) are included to illustrate features of the program.

Key words

FORTRAN Linkage disequilibrium Electrophoresis Breeding structure