Article

Anatomy and Embryology

, Volume 161, Issue 1, pp 115-120

First online:

Development of Dickie's small eye: An early lethal mutation in the house mouse

  • Karl TheilerAffiliated withAnatomisches Institut der Universität Gloriastr. 19
  • , Don S. VarnumAffiliated withThe Jackson Laboratory
  • , Leroy C. StevensAffiliated withThe Jackson Laboratory

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Summary

Mice heterozygous for Dickie's small eye (Dey) are small and have malformed eyes (Theiler et al. 1978). The development of homozygous Dey/Dey was more difficult to analyze than heterozygous Dey/+. This investigation attempted to identify the homozygotes and to distinguish them from Dey/+ and +/+ resorptions. Such a distinction was possible only when enough specimens were available. The mutants are poor breeders and the collection of the necessary material has taken several years.

Key words

Dickie's small eye Development Fetogenesis Mouse