Human Genetics

, Volume 62, Issue 4, pp 327–332

The cell cycle of lymphocytes in Fanconi anemia

  • B. Dutrillaux
  • A. Aurias
  • Anne-Marie Dutrillaux
  • D. Buriot
  • Marguerite Prieur
Original Investigations

DOI: 10.1007/BF00304549

Cite this article as:
Dutrillaux, B., Aurias, A., Dutrillaux, AM. et al. Hum Genet (1982) 62: 327. doi:10.1007/BF00304549

Summary

BrdU-incorporation techniques were used to study the cell cycle in 18 cases of Fanconi's anemia (FA).

By comparison with controls, a significant slowing of the cell cycle of lymphocytes in vitro was observed in all FA patients, and possibly in FA heterozygotes, although to a lesser degree. It is probable that the demonstration of the slowing is dependent on the culture conditions. No slowing was observed in other patients affected by at least one of the symptoms of FA. The slow cell cycle of FA cells is mostly due to a very long G2-phase. A relationship between slow cell cycle and chromatid anomalies exists, the slower cells being significantly more frequently carriers of radial figures than the faster cells, in the same patient.

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • B. Dutrillaux
    • 1
  • A. Aurias
    • 1
  • Anne-Marie Dutrillaux
    • 1
  • D. Buriot
    • 2
  • Marguerite Prieur
    • 1
  1. 1.Institut de ProgenèseParis Cedex 06France
  2. 2.Unité d'Immuno-HématologieHôpital des Enfants-MaladesParisFrance