The effect of a lipid suspension on amitriptyline disposition
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- Minton, N.A., Goode, A.G. & Henry, J.A. Arch Toxicol (1987) 60: 467. doi:10.1007/BF00302392
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A 5-h infusion of a lipid suspension or saline was given on separate occasions to four healthy volunteers taking amitriptyline. Mean plasma levels of amitriptyline plus nortriptyline were 14% higher at the end of the lipid infusion but the difference was not statistically significant. Infusion of a lipid suspension is unlikely to materially affect the severity of amitriptyline intoxication.