Archives of Toxicology

, Volume 60, Issue 6, pp 467–469

The effect of a lipid suspension on amitriptyline disposition


  • N. A. Minton
    • Poisons UnitGuy's Hospital
  • A. G. Goode
    • Guy's Hospital
  • J. A. Henry
    • Poisons UnitGuy's Hospital
Short Communication

DOI: 10.1007/BF00302392

Cite this article as:
Minton, N.A., Goode, A.G. & Henry, J.A. Arch Toxicol (1987) 60: 467. doi:10.1007/BF00302392


A 5-h infusion of a lipid suspension or saline was given on separate occasions to four healthy volunteers taking amitriptyline. Mean plasma levels of amitriptyline plus nortriptyline were 14% higher at the end of the lipid infusion but the difference was not statistically significant. Infusion of a lipid suspension is unlikely to materially affect the severity of amitriptyline intoxication.

Key words

AmitriptylineLipid suspension
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Copyright information

© Springer-Verlag 1987