Calcified Tissue International

, Volume 54, Issue 3, pp 224–230

Coronary arterial calcification as an active process: A new perspective on an old problem

Authors

  • T. M. Doherty
    • Division of CardiologyHarbor-UCLA Medical Center
    • Saint John's Cardiovascular Research Center
  • R. C. Detrano
    • Division of CardiologyHarbor-UCLA Medical Center
    • Saint John's Cardiovascular Research Center
Clinical Investigations

DOI: 10.1007/BF00301683

Cite this article as:
Doherty, T.M. & Detrano, R.C. Calcif Tissue Int (1994) 54: 224. doi:10.1007/BF00301683

Abstract

The mechanism and purpose of coronary atherosclerotic calcification remain unknown. However, evidence reviewed here suggests that calcification is not passive precipitation or adsorption, but instead is organized and regulated. Gla containing proteins and other proteins normally associated with bone metabolism appear to play an important role in this process. A variety of studies are currently in progress in our laboratory which we hope will provide a more comprehensive understanding of processes leading to coronary calcification as well as prognostic data useful in clinical cardiologic practice. A clearer understanding of the nature and significance of coronary calcification may well pave the way toward new interventions to protect myocardium and minimize the morbidity and mortality associated with coronary artery disease.

Key words

Coronary calcificationBone proteins

Copyright information

© Springer-Verlag New York Inc. 1994