Calcified Tissue International

, Volume 55, Issue 6, pp 417–419

Hormone replacement therapy increases serum 1,25-dihydroxyvitamin D: A 2-year prospective study

  • H. J. C. van Hoof
  • M. J. van der Mooren
  • L. M. J. W. Swinkels
  • R. Rolland
  • Th. J. Benraad
Clinical Investigations

DOI: 10.1007/BF00298554

Cite this article as:
van Hoof, H.J.C., van der Mooren, M.J., Swinkels, L.M.J.W. et al. Calcif Tissue Int (1994) 55: 417. doi:10.1007/BF00298554

Abstract

Osteoporosis is a common disorder in postmenopausal women, which is probably due to decreased ovarian function. Currently, hormone replacement therapy (HRT), involving administration of estrogen and progestogen, is successfully applied to reduce bone resorption. We studied the effect of HRT on 23 postmenopausal women. This consisted of a combination of 17β-estradiol and dydrogesterone, on the serum level of 1,25-dihydroxyvitamin D (1,25(OH)2D) after 0, 6, 12, and 24 months. We found mean serum concentrations (±SD) of 1,25(OH)2D of 130.5 pmol/liter (46.1), 152.7 pmol/liter (45.1), 170.8 pmol/liter (64.0), and 155.2 pmol/liter (59.7), respectively. The baseline values in these women were found to be significantly lower than those during therapy (P⩽0.005). No statistically significant differences were observed when comparing the estrogen-only phase with the combined estrogen-progestogen phase. It is concluded that HRT results in an increase in the serum 1,25(OH)2D concentration which lasts for at least 2 years. This increase may partly explain the preventive effect of HRT on osteoporosis. Purthermore, these results suggest that dydrogesterone does not influence the estrogen-induced changes in serum 1,25(OH)2D concentration.

Key words

Vitamin D Cholecalciferol Estrogen Dydrogesterone Postmenopause 

Copyright information

© Springer-Verlag New York Inc. 1994

Authors and Affiliations

  • H. J. C. van Hoof
    • 1
  • M. J. van der Mooren
    • 2
  • L. M. J. W. Swinkels
    • 1
  • R. Rolland
    • 2
  • Th. J. Benraad
    • 1
  1. 1.Department of Experimental and Chemical EndocrinologyUniversity Hospital Nijmegen St. RadboudNijmegenThe Netherlands
  2. 2.Department of Obstetrics and GynecologyUniversity Hospital Nijmegen St. RadboudNijmegenThe Netherlands