Topical treatment with 5-aminosalicylic in distal ulcerative colitis by using a new suppository preparation

A double-blind placebo controlled trial
  • M. Campieri
  • P. Gionchetti
  • A. Belluzzi
  • C. Brignola
  • M. Tampieri
  • P. Iannone
  • P. Brunetti
  • M. Miglioli
  • L. Barbara
Original Articles

DOI: 10.1007/BF00298473

Cite this article as:
Campieri, M., Gionchetti, P., Belluzzi, A. et al. Int J Colorect Dis (1990) 5: 79. doi:10.1007/BF00298473

Abstract

Sixty-two patients with ulcerative colitis localised to the distal sigmoid colon and rectum (<20 cm) entered the trial. Thirty-two were treated with 5-ASA 500 mg suppositories (Asacol) 3 times a day for 1 month while 30 received a placebo given in the same regime. Clinical, sigmoidoscopic and histological assessment was carried out before, after 15 days and after 1 month of treatment. At the end of the study 5-ASA suppositories showed significantly better results in all the parameters recorded than placebo (p<0.01). There were no unwanted effects related to the use of suppositories. This treatment should therefore be offered as a first choice for patients with distal rectosigmoiditis.

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Campieri
    • 1
  • P. Gionchetti
    • 1
  • A. Belluzzi
    • 1
  • C. Brignola
    • 1
  • M. Tampieri
    • 1
  • P. Iannone
    • 1
  • P. Brunetti
    • 2
  • M. Miglioli
    • 1
  • L. Barbara
    • 1
  1. 1.Institute of Clinical Medicine and GastroenterologyUniversity of BolognaItaly
  2. 2.Giuliani Medical DepartmentMilanoItaly