Acta Neuropathologica

, Volume 90, Issue 3, pp 266–272

Endothelial lipopigment as an indicator of α-tocopherol deficiency in two equine neurodegenerative diseases

Authors

  • J. F. Cummings
    • Department of Anatomy, College of Veterinary MedicineCornell University
  • A. de Lahunta
    • Department of Anatomy, College of Veterinary MedicineCornell University
  • H. O. Mohammed
    • Department of Clinical Science, College of Veterinary MedicineCornell University
  • T. J. Divers
    • Department of Clinical Science, College of Veterinary MedicineCornell University
  • B. A. Summers
    • Department of Pathology, College of Veterinary MedicineCornell University
  • B. A. Valentine
    • Department of Pathology, College of Veterinary MedicineCornell University
  • C. A. Jackson
    • Department of Clinical Science, College of Veterinary MedicineCornell University
Regular Paper

DOI: 10.1007/BF00296510

Cite this article as:
Cummings, J.F., de Lahunta, A., Mohammed, H.O. et al. Acta Neuropathol (1995) 90: 266. doi:10.1007/BF00296510

Abstract

Two spontaneous neurodegenerative diseases of the horse, equine motor neuron disease (EMND) and equine degenerative myeloencephalopathy (EDM), have been associated with α-tocopherol deficiency, and both were characterized by prominent accumulations of endothelial lipopigment in the small vessels of the spinal cord. These endothelial pigment deposits appear to be reversible. In EMND horses pasture-supplemented for 9 months or more after the progression of weakness and wasting had arrested, there was very little endothelial lipopigment. The origin and the potential effects of these endothelial lipopigment accumulations are discussed.

Key words

Central nervous system endothelial lipopigmentEquine motor neuron diseaseEquine degenerative myeloencephalopathyVitamin E deficiency

Copyright information

© Springer-Verlag 1995