, Volume 89, Issue 2, pp 194-197

Pleomorphic xanthoastrocytoma with a gangliomatous component: an immunohistochemical and ultrastructural study

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We report a case of 24-year-old woman with left temporal pleomorphic xanthoastrocytoma (PXA) with atypical neuronal cells. Many neoplastic cells, otherwise typical of PXA, expressed glial fibrillary acidic protein, while neuronal cells with marked atypia were immunopositive for synaptophysin and neurofilament protein. This report supports a notion that PXA, like other astrocytic tumors, may have its gangliogliomatous counterpart.