Human Genetics

, Volume 58, Issue 3, pp 344–348

HLA antigens in a sample of the Spanish population: Common features among Spaniards, Basques, and Sardinians

Authors

  • A. Arnaiz-Villena
    • Servicio de ImmunologíaCentro “Ramón y Cajal”
  • S. Rodriguez de Córdoba
    • Servicio de ImmunologíaCentro “Ramón y Cajal”
  • F. Vela
    • Servicio de ImmunologíaCentro “Ramón y Cajal”
  • J. C. Pascual
    • Servicio de ImmunologíaCentro “Ramón y Cajal”
  • J. Cerveró
    • Servicio de ImmunologíaCentro “Ramón y Cajal”
  • A. Bootello
    • Servicio de ImmunologíaCentro “Ramón y Cajal”
Original Investigations

DOI: 10.1007/BF00294935

Cite this article as:
Arnaiz-Villena, A., Rodriguez de Córdoba, S., Vela, F. et al. Hum Genet (1981) 58: 344. doi:10.1007/BF00294935

Summary

Frequencies of recently described HLA-A,-B (antigens or splits) and HLA-C and HLA-DR antigens are studied in a 450 normal Spaniards sample. The linkage disequilibria are also calculated. HLA-DR7 is more frequent than in any other population studied. Aw30-B18 and Aw33-B14 associations are common and specific Spanish, Basque, and Sardinian HLA features. A11-B27 association is found in our Spanish sample and also in Basques.

HLA-Bw4,-Bw6 antigens are analyzed by family mating and segregation and also using unrelated individuals. It shows a good fit as a genetic system. HLA-B antigens are included either in Bw4 or Bw6 according to expectations from other Caucasoid population results. The possibility of a common and North African origen (Iberians) for Spaniards, Basques, and Sardinians is discussed on the basis of presently available HLA data.

Copyright information

© Springer-Verlag 1981