Synthesis and preliminary characterization of polyesteramides containing enzymatically degradable amide bonds
- Cite this article as:
- Castaldo, L., Corbo, P., Maglio, G. et al. Polymer Bulletin (1992) 28: 301. doi:10.1007/BF00294826
Multiblock and regularly alternating biodegradable polyesteramides containing amide bonds susceptible of enzymatic cleavage were prepared and preliminarly characterized by viscosity, IR, 1H-NMR and DSC techniques. L-phenylalanine was used to build up amide linkages containing a phenyl ring adjacent to the acyl group, enzymatically cleavable by chymotrypsin. Monomers having preformed ester groups or biodegradable amide bonds and/or telechelic oligomers of poly(L-lactide) were used as starting materials. Their chain length was regularly increased in order to improve the overall chain flexibility and, hence, to favour the enzymatic attack.