Acta Neuropathologica

, Volume 90, Issue 1, pp 76–79

Detection of two transforming growth factor-β-related morphogens, bone morphogenetic proteins-4 and-5, in RNA of multiple sclerosis and Creutzfeldt-Jakob disease lesions

  • Martin Deininger
  • Richard Meyermann
  • Hermann Schluesener
Short Original Communication

DOI: 10.1007/BF00294462

Cite this article as:
Deininger, M., Meyermann, R. & Schluesener, H. Acta Neuropathol (1995) 90: 76. doi:10.1007/BF00294462
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Abstract

The bone morphogenetic proteins (BMPs) constitute a novel subfamily of the transforming growth factor type β (TGF-β) supergene family. Here we demonstrate, using polymerase chain reaction (PCR) BMP-4 and BMP-5 messages in RNA isolated from multiple sclerosis (MS) plaque tissue. This is the first demonstration of BMP expression in an inflammatory lesion in general, and in MS in particular. However, BMP-4 and BMP-5 messages could be detected in RNA isolated from a Morbus Creutzfeldt-Jakob (CJD) lesion. Even in normal brain, RNA expression of BMP-4, but not that of BMP-5, was detected. Therefore, BMP-5 gene expression seems to be associated with MS and CJD lesions, whereas the BMP-4 gene appears to be constitutively expressed in the human brain. As TGF-βs and BMPs are regulators of regenerative processes and contribute to regulation of chemoattraction and local immunoreactivity, BMP-4 and BMP-5 might be involved in aspects of MS lesion formation unknown so far. PCR analysis of human cell lines demonstrate BMP-4 and BMP-5 expression in leukocytic cells, suggesting that infiltrating leukocytes contribute at least in part to BMP-4 and BMP-5 mRNAs of the MS plaque.

Key words

Bone morphogenetic protein Transforming growth factor-β Multiple sclerosis Morbus Creutzfeldt-Jakob disease 

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Martin Deininger
    • 1
  • Richard Meyermann
    • 1
  • Hermann Schluesener
    • 1
  1. 1.Institute of Brain ResearchUniversity of TübingenTübingenGermany

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