Regular Paper

Acta Neuropathologica

, Volume 90, Issue 1, pp 51-56

First online:

White matter amyloid in Alzheimer's disease brain

  • Toshiki UchiharaAffiliated withDepartment of Neurology, Faculty of Medicine, Tokyo Medical and Dental UniversityDepartment of Neuropathology, Tokyo Institute of PsychiatryLaboratories R. Escourolle, Service de Neuropathologie, Groupe Hospitalier La Petié-La Salpêtrière
  • , Hiromi KondoAffiliated withDepartment of Neuropathology, Tokyo Institute of Psychiatry
  • , Haruhiko AkiyamaAffiliated withDepartment of Neuropathology, Tokyo Institute of Psychiatry
  • , Kenji IkedaAffiliated withDepartment of Neuropathology, Tokyo Institute of Psychiatry

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Abstract

Amyloid β-protein (Aβ) deposits in the white matter were investigated by the double immunohistochemical staining for Aβ and neuritic, glial or vascular components. Reactive astroglia and neurite abnormality were absent around Aβ deposits in the white matter (w-Aβ) even those with a core. The association of w-Aβ with blood vessels was not consistent. Aggregates of activated microglia were found to be the sole but a consistent accompaniment of Aβ deposits even in the absence of other components such as neuron, synapse, neurite abnormality and reactive astroglia, as observed in the white matter. This suggests that the aggregates of activated microglia most likely represent one of the factors promoting the process of Aβ deposition.

Key words

β-Protein White matter Laser scanning microscopy Microglia