Acta Neuropathologica

, Volume 89, Issue 1, pp 23–28

Rapid appearance of β-amyloid precursor protein immunoreactivity in glial cells follwing excitotoxic brain injury

Authors

  • R. Töpper
    • Department of NeurologyTechnical University Aachen
    • Department of NeuromorphologyMax-Planck-Institute of Psychiatry
  • J. Gehrmann
    • Department of NeuromorphologyMax-Planck-Institute of Psychiatry
  • R. Banati
    • Department of NeuromorphologyMax-Planck-Institute of Psychiatry
  • M. Schwarz
    • Department of NeurologyTechnical University Aachen
  • F. Block
    • Department of NeurologyTechnical University Aachen
  • J. Noth
    • Department of NeurologyTechnical University Aachen
  • G. W. Kreutzberg
    • Department of NeuromorphologyMax-Planck-Institute of Psychiatry
Regular Paper

DOI: 10.1007/BF00294255

Cite this article as:
Töpper, R., Gehrmann, J., Banati, R. et al. Acta Neuropathol (1995) 89: 23. doi:10.1007/BF00294255

Abstract

Clinical and experimental data have indicated an up-regulation of amyloid precursor protein (APP) after various types of CNS injury. In the present study the cellular source of lesion-induced APP has been investigated an a neurotoxic CNS model. Quinolinic acid injection into the striatum results in neuronal degeneration, while glial cells survive. APP immunoreactivity was detected in glial cells starting at postoperative day 3 and persisted until day 21, the last time point studied. Double immunocytochemistry identified the majority of APP-immunoreactive cells as glial fibrillary acidic protein-immunoreactive astrocytes. There was no evidence of amyloid fibril deposition during this time. It is concluded that following excitotoxic neuronal degneration APP is mainly produced by reactive astrocytes in the lesioned area.

Key words

Amyloid precursor proteinβ-amyloidQuinolinic acidAstrocytesMicroglia

Copyright information

© Springer-Verlag 1995