Human Genetics

, Volume 69, Issue 2, pp 157–160

The human gene encoding insulin-like growth factor I is located on chromosome 12

  • J. W. M. Höppener
  • P. de Pagter-Holthuizen
  • A. H. M. Geurts van Kessel
  • M. Jansen
  • S. D. Kittur
  • S. E. Antonarakis
  • C. J. M. Lips
  • J. S. Sussenbach
Original Investigations

DOI: 10.1007/BF00293288

Cite this article as:
Höppener, J.W.M., de Pagter-Holthuizen, P., van Kessel, A.H.M.G. et al. Hum Genet (1985) 69: 157. doi:10.1007/BF00293288

Summary

A cDNA probe corresponding to mRNA encoding human somatomedin-C/insulin-like growth factor I (IGF-I) was used for the chromosomal assignment of the IGF-I gene. Southern-blot hybridization analysis of DNA from human-Chinese hamster somatic cell hybrids showed that the IGF-I gene is located on chromosome 12. Comparison of the chromosomal assignments of the IGF-I gene and two other members of the insulin gene family, with three c-ras oncogenes, reveals a remarkable association of the two gene families.

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • J. W. M. Höppener
    • 6
  • P. de Pagter-Holthuizen
    • 1
  • A. H. M. Geurts van Kessel
    • 2
  • M. Jansen
    • 3
  • S. D. Kittur
    • 4
  • S. E. Antonarakis
    • 4
  • C. J. M. Lips
    • 5
  • J. S. Sussenbach
    • 1
  1. 1.Laboratory for Physiological ChemistryState University of UtrechtThe Netherlands
  2. 2.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands
  3. 3.Department of PediatricsState University of UtrechtUtrechtThe Netherlands
  4. 4.Department of PediatricsJohns Hopkins University, School of MedicineBaltimoreUSA
  5. 5.Department of Internal Medicine, State University HospitalState University of UtrechtUtrechtThe Netherlands
  6. 6.Institute of Molecular BiologyState University of UtrechtUtrechtThe Netherlands

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